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  • Title: Rhabdomyolysis after intramuscular iron-dextran in malabsorption.
    Author: Foulkes WD, Sewry C, Calam J, Hodgson HJ.
    Journal: Ann Rheum Dis; 1991 Mar; 50(3):184-6. PubMed ID: 2015014.
    Abstract:
    The case of a 59 year old white man who had chronic malabsorption and selective IgA deficiency with severe iron deficiency is reported. In addition, he was deficient in vitamin E and selenium, important antioxidants which protect against lipid peroxidation. He was intolerant of oral iron and when treated with iron-dextran developed symptoms suggestive of polymyositis with evidence of rhabdomyolysis. It is suggested that free iron within iron-dextran activated free radicals, initiating lipid peroxidation and leading to polymyositis, rhabdomyolysis, and myoglobulinuria.
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