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  • Title: Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine.
    Author: Herchuelz A, Gangji D, Derenne F, Jeanniot JP, Douchamps J.
    Journal: Br J Clin Pharmacol; 1991 Jan; 31(1):73-6. PubMed ID: 2015173.
    Abstract:
    1. Almitrine bismesylate displays wide inter-subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine.
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