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Title: Odorant-evoked potassium changes in the frog olfactory epithelium. Author: Khayari A, Math F, Trotier D. Journal: Brain Res; 1991 Jan 18; 539(1):1-5. PubMed ID: 2015495. Abstract: Electroolfactogram (EOG) and extracellular potassium activity (aK) measurements were carried out in frog olfactory epithelia in vivo. Odorant-evoked changes in aK were characterized on the basis of depth profile analysis. Following an olfactory stimulation with butanol vapours, an increase in aK was measured in the mucus and the proximal part of the epithelium; this response started after the beginning of the EOG and was proportional to the amplitude of the latter. In the deeper part of the epithelium, the aK response had complex waveforms showing an initial K decrease which was suppressed by local application of ouabain, suggesting the existence of a pumping mechanism at this level. The results are discussed in terms of extracellular accumulation of K ions following neuroreceptor activation with respect to EOG generation theories.[Abstract] [Full Text] [Related] [New Search]