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  • Title: Recent advances in the discovery of selective and non-selective 5-HT(1D) receptor ligands.
    Author: Ward SE, Watson JM.
    Journal: Curr Top Med Chem; 2010; 10(5):479-92. PubMed ID: 20166947.
    Abstract:
    This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT(1D) receptor. The field of 5-HT(1D) agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT(1D) receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.
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