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  • Title: Total synthesis of caminoside B, a novel antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia.
    Author: Zhang Z, Zong C, Song G, Lv G, Chun Y, Wang P, Ding N, Li Y.
    Journal: Carbohydr Res; 2010 Apr 19; 345(6):750-60. PubMed ID: 20170905.
    Abstract:
    The first total synthesis of caminoside B, a novel marine antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia, was developed. This marine small molecule inhibitor (IC(50)=20 microM) targeting type III secretory pathway of bacterial pathogenesis was assembled in good yield via a '2+2+1' strategy based on stereocontrolled construction of the four glycosidic linkages.
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