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  • Title: Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.
    Author: Etxeberria A, Mangin JM, Aguirre A, Gallo V.
    Journal: Nat Neurosci; 2010 Mar; 13(3):287-289. PubMed ID: 20173746.
    Abstract:
    We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.
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