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  • Title: Schinalactone A, a new cytotoxic triterpenoid from Schisandra sphenanthera.
    Author: He F, Pu JX, Huang SX, Wang YY, Xiao WL, Li LM, Liu JP, Zhang HB, Li Y, Sun HD.
    Journal: Org Lett; 2010 Mar 19; 12(6):1208-11. PubMed ID: 20180522.
    Abstract:
    A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.
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