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  • Title: A possible prebiotic synthesis of thymine: uracil-formaldehyde-formic acid reaction.
    Author: Choughuley AS, Subbaraman AS, Kazi ZA, Chadha MS.
    Journal: Biosystems; 1977 Sep; 9(2-3):73-80. PubMed ID: 20181.
    Abstract:
    When uracil is reacted with formaldehyde and formic acid in dilute aqueous solutions at 100-140 degrees C, 5-hydroxymethyluracil (5-HMU), methylenebiuracil (MBU) and thymine are formed. It has been shown that 5-HMU is an intermediate in the formation of MBU and thymine. In the presence of formic acid, 5-HMU gives MBU, thymine and in some cases uracil. The formation of thymine is generally favoured under acidic conditions, although small amounts of this base could also be obtained when the reactions were carried out under mildly basic conditions. A hydride ion transfer mechanism is suggested for some of these reactions. These results have relevance to the formation of thymine under prebiotic conditions.
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