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  • Title: Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2).
    Author: Wang M, Zheng DX, Luo MB, Gao M, Miller KD, Hutchins GD, Zheng QH.
    Journal: Appl Radiat Isot; 2010 Jun; 68(6):1098-103. PubMed ID: 20181488.
    Abstract:
    Carbon-11-labeled tariquidar derivatives were first designed and synthesized as new PET agents for imaging of breast cancer resistance protein. The target tracers were prepared by O-[(11)C]methylation of their corresponding acid precursors using [(11)C]CH3OTf under basic conditions and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields based on [(11)C]CO(2) and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111-185 GBq/micromol.
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