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  • Title: Early-onset septicemia due to CMY-2-producing Escherichia coli in a woman with blunt abdominal trauma.
    Author: Chan KS, Yu WL, Kuo CY, Tsai CL, Chuang YC.
    Journal: J Microbiol Immunol Infect; 2009 Oct; 42(5):442-4. PubMed ID: 20182676.
    Abstract:
    Escherichia coli remains one of the most common etiologies of secondary peritonitis. CMY-2 is the most prevalent AmpC enzyme identified in nosocomial E. coli isolates causing bacteremia in Taiwan. This report is of a patient who underwent surgery for intestinal perforations due to blunt abdominal trauma and developed unexpected CMY-2-producing E. coli septicemia in the early postoperative period. The AmpC-type CMY-2 enzyme might partially contribute to the poor response to antimicrobial therapy of amoxicillin-clavulanic acid or flomoxef. Late changes in antibiotic therapy to an appropriate regimen of cefpirome based on the culture results did not result in a positive outcome and the patient died. Whether selection of an anti-AmpC regimen is appropriate as first-line treatment for traumatic abdomen-associated septicemia should be an area of further investigation in Taiwan.
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