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  • Title: Three new eudesmanoids from the Formosan soft coral Nephthea erecta.
    Author: Cheng SY, Wang SK, Wen ZH, Dai CF, Duh CY.
    Journal: J Asian Nat Prod Res; 2009 Nov; 11(11):967-73. PubMed ID: 20183262.
    Abstract:
    Chemical investigations on the organic extract of the Formosan soft coral Nephthea erecta led to the isolation of two new eudesmanoids, (4R*,5S*,6Z,10R*)-8-oxo-eudesm-6-en-5alpha,11-diol (1) and (6E,10R)-4,5-dioxo-11-methoxy-eudesm-6-ene (2), together with one new tri-nor-eudesmane sesquiterpenoid, (4S*,5E,10R*)-7-oxo-tri-nor-eudesm-5-en-4beta-ol (3). The structures of metabolites 1-3 were elucidated through extensive spectroscopic analyses and by comparison with those reported in the literature. The anti-inflammatory activity using RAW 264.7 macrophages and their cytotoxicity against selected cancer cells of 1-3 were evaluated in vitro.
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