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  • Title: Multiorgan failure from 1-benzylpiperazine ingestion--legal high or lethal high?
    Author: Gee P, Jerram T, Bowie D.
    Journal: Clin Toxicol (Phila); 2010 Mar; 48(3):230-3. PubMed ID: 20184432.
    Abstract:
    INTRODUCTION: 1-benzylpiperazine (BZP) is synthetic stimulant. It was legal and openly sold in New Zealand before October 1, 2008. Two cases of life-threatening toxicity associated with BZP use are reported in detail in this article. CASES: Case one describes an adult female who developed status epilepticus, hyperthermia, disseminated intravascular coagulation, rhabdomyolysis, and renal failure associated with a BZP ingestion. Case two developed a similar pattern of toxicity from the combined use of BZP and 3,4-methylenedioxy-N-methylamphetamine. Both cases required prolonged hospital care but survived. DISCUSSION: There have been reports of deaths associated with the combined ingestion of BZP and 3,4-methylenedioxy-N-methylamphetamine. The effects may possibly be synergistic when co-ingested. Case one suggests that BZP alone has the potential to cause serious sympathomimetic toxicity.
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