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  • Title: Stereoselective metabolism of 3-isopropyl-5-(1-naphthoxymethyl)oxazolidine, a prodrug of propranolol.
    Author: Kamal A, Rao AB, Rao MV.
    Journal: Biochem Pharmacol; 1991 May 01; 41(9):1393-5. PubMed ID: 2018570.
    Abstract:
    This investigation suggests that the oxazolidine derivative of propranolol is a prodrug which is hydrolysed stereoselectively to propranolol by hepatic post-mitochondrial supernatant. The (S)-form of the prodrug is more stable in the biological system than its (R)-form.
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