These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Enantiomerically pure polyheterocyclic spiro-beta-lactams from trans-4-hydroxy-L-proline.
    Author: Cremonesi G, Dalla Croce P, Fontana F, La Rosa C.
    Journal: J Org Chem; 2010 Mar 19; 75(6):2010-7. PubMed ID: 20187611.
    Abstract:
    The "Staudinger ketene-imine reaction" between ketenes generated from natural O,N-protected trans-4-hydroxy-l-prolines and the N-benzyl-N-benzylideneamine led to mixtures of diastereoisomeric, enantiomerically pure pyrrolidine-derived spiro-beta-lactams with a relative cis configuration. These were transformed into the corresponding pyrroline-spiro-beta-lactams by means of treatment with a base and the new C=C double bond was submitted to a number of different reactions in order to evaluate its reactivity and obtain new polyheterocyclic enantiomerically pure spiro-beta-lactams.
    [Abstract] [Full Text] [Related] [New Search]