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  • Title: Pd(II)-catalyzed olefination of sp3 C-H bonds.
    Author: Wasa M, Engle KM, Yu JQ.
    Journal: J Am Chem Soc; 2010 Mar 24; 132(11):3680-1. PubMed ID: 20187642.
    Abstract:
    The first Pd(II)-catalyzed sp(3) C-H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding gamma-lactams. Notably, this method was effective with substrates containing alpha-hydrogen atoms and could be applied to effect methylene C-H olefination of cyclopropane substrates.
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