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  • Title: Brief spatial experiences increase granule cell survival in the dentate gyrus of adult rats.
    Author: Feng KL, Wang SP, Wu YS, Lin PY, Tai MY, Tsai YF.
    Journal: Behav Brain Res; 2010 Jun 26; 210(1):143-6. PubMed ID: 20188765.
    Abstract:
    Rats of two experimental groups were placed in an open-field apparatus for 3-5 spatial exploration, each placement lasting 5min (total duration of 15-25min), and had a significantly greater newborn-neuron survival rate of the granule cells than the control group by evaluating the density of 5-bromo-2'deoxyuridine positive cells in the dentate gyrus. This study suggests that brief spatial experiences are sufficient to enhance the survival rate of newborn neurons.
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