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  • Title: Synthesis, characterization and antihypertensive activity of pyridazinone derivatives.
    Author: Siddiqui AA, Mishra R, Shaharyar M.
    Journal: Eur J Med Chem; 2010 Jun; 45(6):2283-90. PubMed ID: 20189270.
    Abstract:
    Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.
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