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  • Title: [Specifics of individual risks in a group of women with genital neoplasms].
    Author: Matei M, Negură L, Carasevici E, Azoicăi D.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2009; 113(4):1216-21. PubMed ID: 20191902.
    Abstract:
    UNLABELLED: Genital cancers represent an important issue regarding women health, as they produce a large number of cases, invalidities and deaths. AIM: The evaluation of individual risks for a group of women with genital neoplasia. MATERIAL AND METHODS: We conducted a pilot case-control study to validate the questionnaire for the evaluation of risk factors in genital cancers, in a number of 40 female subjects (20 cases and 20 controls). We have realized the data processing using the SPSS 16 and EpiInfo 3.5.1. soft wares. RESULTS: For questionnaire validation we have evaluated the reproducibility, the validity, the acceptability and the practicability of the questionnaire. In order to establish the test reproducibility, we have calculated k factors for inter-investigator (k = 0.34) and intra-investigator (k = 0.72) variation. To evaluate the questionnaire validity we calculated the sensitivity (cases = 94%; controls = 97%), specificity (cases = 67%, controls = 75%), positive predictive value (cases = 94%; controls = 94%), negative predictive value (cases = 67%; controls = 86%). The risk factors most frequently identified were genital infectious in clinical records (75% comparing to 52.5% - p = 0.036), and also the presence of other pathological records in genital area (65% comparing to 22.5% - p = 0.0001). CONCLUSIONS: For an accurate identification of individual risk at women with genital cancers subsequently studies on greater number of subjects is necessary.
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