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  • Title: Banded collagen in the kidney with special reference to collagenofibrotic glomerulopathy.
    Author: Khubchandani SR, Chitale AR, Gowrishankar S.
    Journal: Ultrastruct Pathol; 2010 Apr; 34(2):68-72. PubMed ID: 20192702.
    Abstract:
    BACKGROUND: The normal glomerular basement membrane, composed of type IV collagen, plays an important function in the process of filtration. Rarely, type III, type I, or type V collagen is seen in the glomerulus, resulting in three different types of non-immune mediated glomerulopathies recognized thus far. These are characterized by deposition of banded collagen fibers in the glomerulus. METHODS: The authors reviewed 4934 kidney biopsies submitted over the past 5 years. Five of these revealed the presence of banded collagen in the glomeruli. CONCLUSION: Combined clinical and ultrastructural examination has led to a definitive diagnosis. These diseases exhibit indolent progression and as yet do not have specific treatment.
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