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  • Title: MSH/ACTH4-10 influences on the CAR in human subjects: a negative finding.
    Author: Miller LH, Fischer SC, Groves GA, Rudrauff ME.
    Journal: Pharmacol Biochem Behav; 1977 Nov; 7(5):417-9. PubMed ID: 201937.
    Abstract:
    Twenty normal, male, paid volunteers were randomly assigned to MSH/ACTH4-10 or diluent control groups. Following a subcutaneous injection of either 30 mg MSH/ACTH4-10 or diluent, all subjects were placed in an active conditioned avoidance response situation where they learned to avoid a painful electric shock by pressing a key during a safe interval between a warning signal (light) and shock onset. MSH/ACTH4-10 did not influence any parameter of the acquisition or extinction process. The between subjects' variability of autonomic variables was significantly less for the MSH/ACTH4-10 group. Results indicate that inhibition of extinction of conditioned avoidance responding does not generalize across species from rat to man.
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