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  • Title: Systematized contact dermatitis and montelukast in an atopic boy.
    Author: Castanedo-Tardan MP, González ME, Connelly EA, Giordano K, Jacob SE.
    Journal: Pediatr Dermatol; 2009; 26(6):739-43. PubMed ID: 20199453.
    Abstract:
    Upon ingestion, the artificial sweetener, aspartame is metabolized to formaldehyde in the body and has been reportedly associated with systemic contact dermatitis in patients exquisitely sensitive to formaldehyde. We present a case of a 9-year-old Caucasian boy with a history of mild atopic dermatitis that experienced severe systematized dermatitis after being started on montelukast chewable tablets containing aspartame. Patch testing revealed multiple chemical sensitivities which included a positive reaction to formaldehyde. Notably, resolution of his systemic dermatitis only occurred with discontinuation of the montelukast chewables.
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