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  • Title: Randomized trial of enteral protein and energy supplementation in infants less than or equal to 1250 g at birth.
    Author: Brumberg HL, Kowalski L, Troxell-Dorgan A, Gettner P, Konstantino M, Poulsen JF, Ehrenkranz RA.
    Journal: J Perinatol; 2010 Aug; 30(8):517-21. PubMed ID: 20200540.
    Abstract:
    OBJECTIVE: To determine if enteral protein and energy supplementation would significantly improve weight gain as compared with energy supplementation alone in <or=1250 g infants. STUDY DESIGN: Inclusion criteria were birth weight (BW) <or=1250 g, postnatal age >or=14 days, diet of >or=75% enteral nutrition (fortified human milk or formula) and either failure to regain BW or weight gain<15 g kg(-1) per days. Infants were randomized to a multinutrient supplement that provided increased protein and energy (P/E) intake or energy alone (medium chain triglyceride oil, MCT). Growth rates were compared at the end of the 4-week study period. RESULT: Of 30 eligible infants, 23 were enrolled, 12 received MCT (BW=862+/-252 g, mean+/-s.d.) and 11 received P/E (BW=879+/-241 g). Significantly higher protein intake (P/E=3.5+/-0.3 g kg(-1) per day, MCT=3.0+/-0.5 g kg(-1) per day) and better growth (P/E=17.0+/-2.4 g kg(-1) per day, MCT=11.5+/-4.8 g kg(-1) per day) were observed in the P/E group. CONCLUSION: These data are consistent with the importance of providing additional daily protein intake to achieve increased postnatal growth in very low birth weight infants experiencing slow growth.
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