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  • Title: Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose.
    Author: Hantson P, Di Fazio V, Wallemacq P.
    Journal: Drug Metab Lett; 2010 Jan; 4(1):7-8. PubMed ID: 20201782.
    Abstract:
    A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.
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