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  • Title: A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection.
    Author: Wen SW, Leader A, White RR, Léveillé MC, Wilkie V, Zhou J, Walker MC.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2010 Jun; 150(2):160-5. PubMed ID: 20207067.
    Abstract:
    OBJECTIVE: To assess the association between in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and adverse birth outcomes. STUDY DESIGN: Retrospective cohort study involved IVF/ICSI patients who were treated in the Ottawa Fertility Centre from 1996 to 2005 with a viable pregnancy (>20 weeks of gestation) and mothers who conceived naturally. RESULTS: Eleven of the 1044 infants conceived with IVF/ICSI (1.1%) and 7 of the 1910 naturally conceived infants (0.4%) had congenital heart defects (P<0.01). Five of the 138 infants (3.6%) born to mothers with a body mass index>30 and conceived by IVF/ICSI had congenital heart defects, compared with none in the 240 infants born to mothers with a body mass index>30 and conceived naturally (P<0.01). CONCLUSION: Infants conceived with use of IVF/ICSI have three times as high a risk of a congenital heart defect as naturally conceived infants.
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