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  • Title: Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach.
    Author: Zhang HS, Feng DZ, Chen L, Long YQ.
    Journal: Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2219-23. PubMed ID: 20207141.
    Abstract:
    By using functionality inversion approach, we identified a new scaffold containing (S)-alpha-phenyl-gamma-amino butanamide as CCR5 antagonists derived from the 1,3-propanediamine carboxamide pharmacophore protocol. The (2S)-2-phenyl-4-(8-aza-bicyclo[3.2.1]octan-8-yl)-butanamide derivatives display significantly high potency to antagonize CCR5 receptor with nanomolar IC(50) values.
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