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  • Title: Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging.
    Author: Kim C, Qin R, Xu JS, Wang LV, Xu R.
    Journal: J Biomed Opt; 2010; 15(1):010510. PubMed ID: 20210423.
    Abstract:
    We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.
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