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  • Title: A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/ clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris.
    Author: Jackson JM, Fu JJ, Almekinder JL.
    Journal: J Drugs Dermatol; 2010 Feb; 9(2):131-6. PubMed ID: 20214175.
    Abstract:
    BACKGROUND: Combination products in which the individual components have different mechanisms of antimicrobial action have been shown in many disease states to provide the most effective therapy. METHODS: This 16-week, two-center, investigator-blinded, randomized, parallel-group study evaluated the antimicrobial efficacy of clindamycin phosphate 1%/benzoyl peroxide 5% gel (BPO/C) as compared to a clindamycin phosphate 1.2%/tretinoin 0.025% gel (T/C) over 16 weeks in the treatment of moderate to moderately severe acne. RESULTS: While subjects in both arms experienced reductions in total Propionibacterium acnes (P. acnes) counts, the BPO/C arm produced greater reductions throughout the study. Furthermore, overall reductions in the number of clindamycin-resistant and erythromycin-resistant P. acnes occurred only in BPO/C treated subjects. CONCLUSION: These data suggest that clindamycin phosphate 1%/benzoyl peroxide 5% gel reduces P. acnes counts and mitigates the emergence of antimicrobial resistance.
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