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  • Title: Immunohistochemical and ultrastructural analysis of medullary carcinoma of the thyroid in relation to hormone production.
    Author: Kameya T, Shimosato Y, Adachi I, Abe K, Kasai N, Kimura K, Baba K.
    Journal: Am J Pathol; 1977 Dec; 89(3):555-74. PubMed ID: 202164.
    Abstract:
    Eighteen cases of medullary carcinoma of the thyroid were analyzed immunohistochemically for calcitonin- and ACTH-containing cells, and tumor cells in 8 cases were examined by an electron microscope and analyzed by manual and computer procedures with particular attention paid to the size and quality of secretory granules. Calcitonin- and ACTH-containing cells were found singly or in clusters in 14 and 11 tumors, respectively. In 4 cases, calcitonin-positive cell clusters and an increase in number of singly scattered C cells were seen apart from the main tumor, suggesting a multicentric nature of certain medullary carcinomas. Some ACTH-containing cells were apparently also positive for calcitonin. In a case of familial Sipple disease, follicular lining cells were replaced in areas with ACTH-containing cells. Three to five frequency distribution curves of the size of secretory granules were obtained in all of 6 cases analyzed, and at least two different types of granule matrix were identified.
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