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  • Title: Prevalence of factor V leiden mutation in patients with thrombosis in Tunisia.
    Author: Ajem A, Slama A, Slama FB, Mehjoub T.
    Journal: East Mediterr Health J; 2009; 15(6):1483-8. PubMed ID: 20218141.
    Abstract:
    This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients (102 with venous thrombosis and 26 with arterial thrombosis) attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients (20.3%) than controls (6.0%). The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified.
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