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  • Title: Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.
    Author: Lakhkar N, Abou Neel EA, Salih V, Knowles JC.
    Journal: J Biomater Appl; 2011 May; 25(8):877-93. PubMed ID: 20219848.
    Abstract:
    This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).
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