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  • Title: Cold agglutinin induced hemolysis in a newly diagnosed systemic lupus erythematosus.
    Author: Srinivasan N, Oswal A, Garg S, Nahar J, Gosmonova A, Nahar R.
    Journal: Am J Med Sci; 2010 Mar; 339(3):270-3. PubMed ID: 20220336.
    Abstract:
    Systemic lupus erythematosus (SLE) is a well-known autoimmune chronic inflammatory disease, which can virtually affect any organ system in the body. Although hemolytic anemia has been known to occur in <10% of SLE patients, they are usually mediated through warm antibodies. It is extremely rare to see cold antibody-mediated hemolytic anemia in SLE, and only few cases have been reported in literature to our knowledge. This is a unique case report of SLE associated with cold agglutinin hemolytic anemia in a patient presented with generalized tender lymphadenopathy and typical B-symptoms including fever, night sweats, and significant weight loss.
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