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  • Title: [Preparation and in vitro release characteristics of curcumin loaded biodegradable microspheres].
    Author: Wang H, Li P, Zhang L, Zhang J, Ling X, Ran H.
    Journal: Zhongguo Zhong Yao Za Zhi; 2009 Dec; 34(23):3021-4. PubMed ID: 20222415.
    Abstract:
    OBJECTIVE: To prepare curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres and study its release characteristics in vitro. METHOD: Curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres were prepared by W/O/W emulsification solvent-evaporation process. The microspheres were characterized in terms of morphology, size, encapsulation efficiency, the rate of drug loading and in vitro drug release. RESULT: The formed microspheres were spherical with smooth surfaces. The distribution of particle size was uniform and average size was 1 151 nm. The rate of drug loading was (1.98 +/- 0.14)% and the encapsulation efficiency was (59.44 +/- 4.05)%. In vitro release study revealed that the 71-hour accumulative release percentage reached 77%. CONCLUSION: Curcumin loaded poly-(D,L-lactide-co-glycolide) microspheres are prepared successfully and show good sustained-release characteristics.
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