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  • Title: Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction.
    Author: Kovo M, Schreiber L, Ben-Haroush A, Wand S, Golan A, Bar J.
    Journal: Am J Obstet Gynecol; 2010 Jun; 202(6):561.e1-5. PubMed ID: 20223448.
    Abstract:
    OBJECTIVE: Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders. STUDY DESIGN: Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease. RESULTS: Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004). CONCLUSION: Placental lesions correspond with different clinical presentations.
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