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  • Title: Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of rapamycin (mTOR) with selectivity over PI3Kalpha.
    Author: Richard DJ, Verheijen JC, Yu K, Zask A.
    Journal: Bioorg Med Chem Lett; 2010 Apr 15; 20(8):2654-7. PubMed ID: 20223664.
    Abstract:
    Potent inhibitors of the mammalian target of rapamycin (mTOR) which contain the triazine scaffold and the (R)-3-methyl morpholine moiety have been identified. Such compounds also demonstrated good selectivity over the related lipid kinase PI3Kalpha. Incorporation of additional functionality at the 4-position of the arylureidophenyl ring resulted in compounds with enhanced cellular activity.
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