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  • Title: Transport-based quantitative photoacoustic tomography: simulations and experiments.
    Author: Yao L, Sun Y, Jiang H.
    Journal: Phys Med Biol; 2010 Apr 07; 55(7):1917-34. PubMed ID: 20224160.
    Abstract:
    In this paper we describe a method for quantitative photoacoustic tomography (qPAT) based on the photon radiative transfer equation (RTE) coupled with the Helmholtz photoacoustic wave equation. Considerable simulations and tissue-like phantom experiments are conducted to evaluate transport-based qPAT in comparison with diffusion-based qPAT. In these comparative simulations and experiments, we systematically examine the effects of the ratio of mu(a)/mu'(s) (absorption/reduced scattering coefficient), the anisotropy factor (g) and the imaging domain size on the transport- and diffusion-based photoacoustic image reconstruction. The results obtained show that transport-based qPAT allows for clearly more accurate recovery of the absolute absorption coefficient images of heterogeneous media over diffusion-based qPAT for all the cases examined and provides considerably improved image quality for cases where the photon diffusion approximation (DA) is invalid.
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