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  • Title: Evaluation of acute renal failure with magnetic resonance imaging using gradient-echo and Gd-DTPA.
    Author: Munechika H, Sullivan DC, Hedlund LW, Beam CA, Sostman HD, Herfkens RJ, Pelc NJ.
    Journal: Invest Radiol; 1991 Jan; 26(1):22-7. PubMed ID: 2022449.
    Abstract:
    Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 micrograms/kg/min) into the renal arteries for 40 minutes. MRI was performed 1 hour later and compared with baseline (pre-ARF) MRI. There was no significant difference in the ratios of signal intensity-vs.-time curves from 0 to 35 seconds after injection of Gd-DTPA. However, a difference between the outer and inner medulla was significant in the time period of 5 to 20 minutes after Gd-DTPA injection. These later signal intensity differences by fast-scan (gradient-echo) technique may be useful in the evaluation of ARF.
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