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  • Title: A novel series of cytotoxic iridoid glucosides derived from aucubin: design, synthesis and structure-activity relationships.
    Author: Rakotondramasy VC, Mouriès C, Cachet X, Neghra A, El Mourabet M, Tillequin F, Koch M, Deguin B.
    Journal: Eur J Med Chem; 2010 Jun; 45(6):2314-20. PubMed ID: 20227146.
    Abstract:
    Five new unsaturated iridolactones 3-7 related to natural cytotoxic oxylipins, Tei 9826, and iridolactone 2, were prepared by parallel synthesis from natural aucubin. It was found that perpivaloyl iridoid glucosides 2, 3, and 4 were markedly cytotoxic against both L1210 and KB-3-1 cell lines.
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