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  • Title: Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine.
    Author: Bandari S, Eaga CM, Thadishetty A, Yamsani MR.
    Journal: Acta Pharm; 2010 Mar; 60(1):89-97. PubMed ID: 20228043.
    Abstract:
    A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
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