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  • Title: [Expression and its significance of connective tissue growth factor in articular cartilage during repair after full-thickness cartilage injury in young rabbit model].
    Author: Fu JJ, Chu TW, Zhou Y, Liu YG.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2010 Feb; 26(2):132-4. PubMed ID: 20230672.
    Abstract:
    AIM: To approach the expression and its significance of connection tissue growth factor in articular cartilage during repair after full-thickness cartilage injury in young rabbit model. METHODS: Young rabbit model of spontaneous healing of full-thickness cartilage defect in the medial femoral knee condyle was reproduced in present study. A total of twenty-five young New Zealand white rabbit were randomly divided into five groups: control group, 24 hour group, 1 week group, 4 week group and 8 week group after full-thickness cartilage injury (5 each). The mRNA and protein expression of CTGF were detected with RT-PCR and immunohistochemistry, respectively. RESULTS: The morphologically good repairs with hyaline-like cartilage appearance were observed at 8 weeks after injury. The expression of CTGF mRNA was detected in all groups. Expression of CTGF mRNA was significantly higher in all groups after cartilage injury than in control group(P<0.05).The immunohistochemistry results showed that the expression of CTGF was positive in all groups, and immunolocalization was observed in the middle and deep zone. CONCLUSION: The up-regulated expression of CTGF is accompanied with spontaneous healing of full-thickness cartilage defect in young rabbit, and CTGF may play a role in the repair of articular cartilage injury.
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