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  • Title: The operation of the malate-aspartate shuttle in the reoxidation of glycolytic NADH in slices of fetal rat liver.
    Author: Dani A, Bartoli GM, Galeotti T.
    Journal: Biochim Biophys Acta; 1977 Dec 23; 462(3):781-4. PubMed ID: 202312.
    Abstract:
    Lactate production by liver slices from fetal rats (17th--18th day of gestation) is enhanced about two fold by aminooxyacetate, an inhibitor of aspartate transaminase (EC 2.6.1.1). Such an effect is consistent with an increase of the cytosolic NAD-redox state owing to the parallel fall in the pyruvate level, whereas the glycolytic flux does not seem to be influenced appreciably. Indeed, although the inhibitor causes a marked increase of fructose 1,6-diphosphate, glucose-6-phosphate decreases only slightly. These results suggest that in fetal rat liver the malate-aspartate shuttle is operative in the reoxidation of cytosolic NADH produced during aerobic glycolysis.
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