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  • Title: Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus.
    Author: Silverman E, Mamula M, Hardin JA, Laxer R.
    Journal: J Rheumatol; 1991 Jan; 18(1):120-4. PubMed ID: 2023181.
    Abstract:
    Previous studies have suggested a role for anti-Ro antibodies in the pathogenesis of neonatal lupus erythematosus (NLE). We reexamined the role of the immune response to the Ro/La particle in the development of NLE using newer and more definitive assay techniques. All 15 infants with congenital heart block and NLE had both anti-Ro and anti-La antibodies. Of 8 patients with cutaneous NLE alone, 2 had anti-Ro antibodies alone while the remaining 6 had both anti-Ro and anti-La antibodies. One woman gave birth to 2 children; one had both Ro and La antibodies and developed congenital heart block, the other had only anti-Ro and anti-U1RNP antibodies and was clinically normal. Our study demonstrates that the presence of anti-Ro and anti-La antibodies define the immune response that is associated with the development of congenital heart block of NLE.
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