These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Key players in the gene networks guiding ESCs toward mesoderm.
    Author: Omelyanchuk N, Orlovskaya IA, Schraufstatter IU, Khaldoyanidi SK.
    Journal: J Stem Cells; 2009; 4(3):147-60. PubMed ID: 20232600.
    Abstract:
    Embryonic stem cells (ESCs) offer a powerful in vitro model to study mechanisms implicated in cell fate decision. Developmental pathways by which pluripotent ESCs become committed to specific lineages are reflected in dynamic changes of signaling and transcriptional programs. However, the mechanisms that govern the regulatory intracellular networks underlying lineage fate decisions and differentiation programs remain poorly understood and differ significantly in different species. In this review we analyze the current understanding of the signaling mechanisms and transcriptional regulation of differentiation of murine and human ESCs into the mesoderm.
    [Abstract] [Full Text] [Related] [New Search]