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  • Title: Highly enantioselective hydrogenation of alpha-arylmethylene cycloalkanones catalyzed by iridium complexes of chiral spiro aminophosphine ligands.
    Author: Xie JB, Xie JH, Liu XY, Kong WL, Li S, Zhou QL.
    Journal: J Am Chem Soc; 2010 Apr 07; 132(13):4538-9. PubMed ID: 20232874.
    Abstract:
    The highly efficient asymmetric hydrogenation of alpha-arylmethylene cycloalkanones catalyzed by Ir-complexes of chiral spiro aminophosphine ligands was developed, providing chiral exo-cyclic allylic alcohols at high yields with excellent enantioselectivities (up to 97% ee) and high turnover numbers (S/C up to 10,000). This new reaction provided an efficient method for the synthesis of the key intermediate of the active form of the anti-inflammatory loxoprofen.
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