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  • Title: Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA).
    Author: Pitsinos E, Athinaios N, Xu Z, Wang G, Negishi E.
    Journal: Chem Commun (Camb); 2010 Apr 07; 46(13):2200-2. PubMed ID: 20234905.
    Abstract:
    (+)-Scyphostatin (1) was synthesized via (i) construction of a side-chain 3b of > or = 98% purity in 19% yield in eleven steps featuring ZACA reaction, Negishi coupling, and HWE olefination, (ii) an asymmetric synthesis of a fully protected core 4 from 10a, and (iii) a three-step assembly of 1 in 42% yield.
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