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  • Title: [Activity of glucose-6-phosphate metabolism enzymes in the livers of rats with experimental valekson poisoning].
    Author: Kuz'minskaia UA, Bersan LV, Pis'mennaia MV.
    Journal: Biull Eksp Biol Med; 1977 Dec; 84(12):677-9. PubMed ID: 202353.
    Abstract:
    The activity of hexokinase, glucose-6-phosphatase and glucose-6-phosphoric dehydrogenase was studied in the liver of rats after one hour, one and five days after a single oral administration of organic phosphorus insecticide valekson. It was determined that administration of the preparation led to an increase of activity in the homogenate and solubilization of glucose-6-phosphatase, activation of glucose-6-phosphoric dehydrogenase and inhibition of hexokinase. The changes were maximum one hour after the administration of the compound. The results show that a decrease of the intensity of glucose-6-phosphate formation and metabolism is one of the pathogenetic factors in the development of valekson-induced intoxication.
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