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  • Title: Collagenous myofibroblastic tumor of the mandible: case report of a unique locally aggressive neoplasm.
    Author: Nash JW, Hessel AC, Vigneswaran N, El-Naggar AK.
    Journal: Head Neck Pathol; 2010 Mar; 4(1):44-8. PubMed ID: 20237988.
    Abstract:
    We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.
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