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  • Title: Two mechanisms of isoproterenol inhibition of smooth muscle.
    Author: Overweg NI, Schiff JD.
    Journal: Eur J Pharmacol; 1978 Jan 15; 47(2):231-3. PubMed ID: 202471.
    Abstract:
    The relaxation of depolarized ideal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid beta-adrenergic mechanism independent of cAMP as well as a slower cAMP-dependent relaxation. This dual process model for beta-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.
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