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  • Title: [Preservation of Claviceps purpurea, the producer of peptide ergot alkaloids, by the method of freeze drying].
    Author: Ustiuzhanina SV, Sarkisova MA, Gorin SE.
    Journal: Antibiot Khimioter; 1991 Feb; 36(2):6-8. PubMed ID: 2025122.
    Abstract:
    A saprotrophic strain of Claviceps purpurea VNIIA 312A, an organism producing peptide +ergot alkaloids with prolactin inhibiting activity was shown to die under lyophilization conditions. To provide long-term storage of strain 312A, L-drying or drying under vacuum from liquid state was used with success. Three protective media were tested. Favourable results were obtained by using 25 per cent maltose solution as a protective medium. Preservation of the culture viability was accompanied by maintenance of the culture capacity for active formation of the biomass and production of +ergot alkaloids.
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