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  • Title: Identification and partial characterisation of a serum enzyme which hydrolyses epidermal inhibitory pentapeptide.
    Author: Whitehead PA, Robinson PA, Hume WJ, Keen JN.
    Journal: Biochem Biophys Res Commun; 1991 Mar 29; 175(3):978-85. PubMed ID: 2025267.
    Abstract:
    We have identified an enzyme present in mammalian, avian, and reptilian serum which cleaves epidermal inhibitory pentapeptide (pGlu-Glu-Asp-Ser-GlyOH) to form a relatively stable tripeptide (pGlu-Glu-Asp). The enzyme has an inhibitor profile unlike any readily identifiable serum enzyme, and is stable at 4 degrees C for up to 3 months. As most experiments using the pentapeptide are carried out in the presence of serum this finding may have important implications on future research into the biological function of the pentapeptide.
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