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  • Title: Comparison of topical Xylocaine with placebo as a local anesthetic in colposcopic biopsies.
    Author: Prefontaine M, Fung-Kee-Fung M, Moher D.
    Journal: Can J Surg; 1991 Apr; 34(2):163-5. PubMed ID: 2025805.
    Abstract:
    Colposcopically directed biopsies cause discomfort for the patient. Topical lidocaine (Xylocaine) had routinely been applied to the cervix before biopsies performed at the colposcopy clinic of the Ottawa General Hospital. A prospective, single-blind trial was performed to compare the effect of topical Xylocaine with that of a placebo. Patients in both groups experienced discomfort; the median pain score in both groups was equal, and statistical analysis of the results by the Mann-Whitney test showed no difference between the two treatment groups.
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